Efficacy of brachytherapy with californium-252 neutrons versus cesium-137 photons for eradication of bulky localized cervical cancer: single-institution study

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · JNCI, J. Natl. Cancer Inst.; (United States)

DOI:https://doi.org/10.1093/jnci/80.7.501· OSTI ID:6937769

Maruyama, Y; van Nagell, J R; Yoneda, J; Donaldson, E; Gallion, H; Higgins, R; Powell, D; Turner, C; Kryscio, R

A fast-neutron-emitting radioisotope, /sup 252/Cf, is being tested in clinical trials of neutron brachytherapy for cervical cancer. The efficacy for histological eradication of bulky stage IB cervical tumors (mean diameter, approximately 6 cm) using combined radiation and surgery was studied in 65 patients treated with /sup 137/Cs or /sup 252/Cf before surgery during 1983-1986. Forty-four patients were treated with /sup 137/Cs and 21 were treated with /sup 252/Cf at equivalent doses of radiation. Fifteen of the 44 specimens (34%) were positive after 137Cs therapy. Only one of the 21 specimens was positive after /sup 252/Cf therapy (P = .025), and that patient was treated in a delayed schedule 21 days after the start of external-beam irradiation rather than early in the course. /sup 252/Cf therapy required a much lower radiation dose and shorter treatment time. The study compared tumor destruction of an identically staged human cervical tumor in situ by direct histological means, using /sup 252/Cf neutron therapy or conventional photon therapy at an identical and equivalent dose adjusted by a relative biological effectiveness of 6.0 for /sup 252/Cf.

• Research Organization: Univ. of Kentucky Medical Center, Lexington (USA)
• OSTI ID: 6937769
• Journal Information: JNCI, J. Natl. Cancer Inst.; (United States), Journal Name: JNCI, J. Natl. Cancer Inst.; (United States) Vol. 80:7; ISSN JJIND
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALI METAL ISOTOPES
ALPHA DECAY RADIOISOTOPES
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CESIUM 137
CESIUM ISOTOPES
COMPARATIVE EVALUATIONS
DISEASES
DOSES
ELEMENTARY PARTICLES
EVEN-EVEN NUCLEI
FEMALE GENITALS
FERMIONS
HADRONS
HEAVY NUCLEI
ISOTOPES
MEDICINE
NEOPLASMS
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
THERAPY
UTERUS
YEARS LIVING RADIOISOTOPES