/sup 125/I interstitial implants in the RIF-1 murine flank tumor: an animal model for brachytherapy

Journal Article · Wed Sep 01 00:00:00 EDT 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575897· OSTI ID:6707973

Bernstein, M; Gutin, P H; Weaver, D A; Deen, D F; Barcellos, M H

The development of a model for interstitial brachytherapy that uses high-activity, removable /sup 125/I sources in the RIF-1 murine flank tumor is reported. Experimental end points are clonogenic cell and tumor regrowth delay assays. For the clonogenic cell assay, interestitial radiation is delivered at total doses of 500-10,000 rad at dose rates of 0.9-2.7 rad/min to cells in annuli of tissue in the tumor. Dose-survival curves are characterized by an initial shoulder followed by a straight (exponential) portion, with D/sub 0/ similar to that of the curve obtained by external irradiation of the RIF-1 tumor in a self-contained cesium irradiator at similar dose rates. Tumor regrowth curves have been obtained for minimum tumor doses of 500-5000 rad; marked tumor regression has been observed with minimum tumor doses as low as 2000 rad, but results are not as reproducible as the results obtained with the clonogenic cell assay.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 6707973
• Journal Information: Radiat. Res.; (United States), Vol. 91:3
• Country of Publication: United States
• Language: English

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