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Effect of combination treatment with cis-platinum and low dose rate /sup 125/I radiation in a murine brachytherapy model

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The effect of combination treatment with cis-platinum during low dose rate irradiation from /sup 125/I sources in the RIF-1 murine flank tumor model was studied. Cell survival measured with a colony forming efficiency assay was used as the experimental endpoint. When 3 mg/kg of cis-platinum was administered 24, 12, and 1 hr before or 0, 12 and 24 hr after irradiation, the effect on cell kill was additive. Thus in the RIF-1 model there is no particular advantage gained by treatment with the combinations of cis-platinum and /sup 125/I radiation used in these studies.
Research Organization:
Univ. of California, San Francisco
OSTI ID:
6407689
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:8; ISSN IOBPD
Country of Publication:
United States
Language:
English