Enhancement of high intensity Iodine-125 brachytherapy by cis-platinum in a murine bladder tumor model
Journal Article
·
· J. Urol.; (United States)
OSTI ID:6201061
The interaction of cis-platinum chemotherapy and high-intensity Iodine-125 brachytherapy was studied in C3H/He mice with MBT-2 tumors growing in the thigh. Brachytherapy was delivered by 3 Iodine-125 seeds of 10 mCi each implanted into the tumor. Ninety-six animals were randomly divided into 8 groups of 12 animals each. Each group was given either no treatment (control), cis-platinum alone or brachytherapy of 20, 40 or 50 Gy either alone or combined with cis-platinum. Cis-platinum 3 mg. per kg. was given every 5 days for 3 doses. The addition of cis-platinum enhanced the effects of Iodine-125 brachytherapy as shown by the end-points of tumor regrowth delay, local tumor control and median survival times. The sensitization enhancement ratio ranged from 1.2 to 1.9. Further experiments are to be conducted to study the normal tissue effect, therapeutic gain factor, effects of altering the time of administration of cis-platinum and the clinical use of high-intensity Iodine-125 for removable brachytherapy.
- Research Organization:
- Univ. of Tennessee Center for the Health Sciences, Memphis
- OSTI ID:
- 6201061
- Journal Information:
- J. Urol.; (United States), Journal Name: J. Urol.; (United States) Vol. 131:6; ISSN JOURA
- Country of Publication:
- United States
- Language:
- English
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Wed Aug 01 00:00:00 EDT 1979
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
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OSTI ID:5331837
Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLADDER
BODY
CHEMOTHERAPY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL NEOPLASMS
IMPLANTS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MICE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PLATINUM COMPOUNDS
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RODENTS
SURVIVAL TIME
THERAPY
TRANSITION ELEMENT COMPOUNDS
URINARY TRACT
VERTEBRATES
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLADDER
BODY
CHEMOTHERAPY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL NEOPLASMS
IMPLANTS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MICE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PLATINUM COMPOUNDS
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RODENTS
SURVIVAL TIME
THERAPY
TRANSITION ELEMENT COMPOUNDS
URINARY TRACT
VERTEBRATES