Radiation therapy and cis-diammine-dichloroplatinum (II) in transplantable and primary murine bladder cancer

Conference · Wed Aug 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5331837

Soloway, M S; Morris, C R; Sudderth, B

Preoperative radiation improves survival in advanced bladder cancer but the high failure rate, primarily due to distant metastases, suggests a need for adjuvant chemotherapy. The optimal drug might exhibit an additive effect with radiotherapy. Transitional cell carcinoma (TCC) induced in mice by FANFT closely resembles the human counterpart, and both primary and transplanted tumors were used to evaluate the possible additive effect of cis DDP and cyclophosphamide (CY), two drugs with activity in TCC, with radiation. One hundred C3H/He mice had 5 x 10/sup 4/ TCC cells placed in their right hind limbs and randomized into a control (20) and 8 treatment groups (10); 3600 rad, 3600 rad + CY, 3600 rad + cis DDP, 1500 rad + cis DDP, 1500 rad + CY, CY, and cis DDP. Chemotherapy was initiated on day 7 and continued every week x 3. Radiation, in 250 rad or 600 rad fractions, was given biweekly to the tumor bearing limb using a CO/sub 60/ source. 3600 rad alone produced 60% cures with a significant reduction in average tumor diameter (p < 0.001). 3600 rad + cis DDP achieved 78% cures, the best regimen. Therapy of palpable tumors yielded similar results--ave. tumor diameter (D-38) for controls 16.5, 3000 rad--10.6 (p < 0.001), cis DDP--10.2, CY + 1600 rad--8.1, cis DDP + 300 rad--6.2. Cis DDP + 3000 rad was significantly better than cis DDP or 3000 rad alone. One hundred fifty mice ingesting FANFT for 11 months were randomized into 7 groups and subjected to the same regimens to evaluate the effect on primary tumors. The greatest reduction in tumor volume was in mice receiving 1500 rad + cis DDP (mean bladder weight, 29.68 vs. controls 53.57, p < 0.005). These results consistently suggest cooperation between irradiation and cis DDP. Adjuvant cis DDP for invasive bladder cancer might be maximized by initiation with preoperative radiotherapy. Our initial clinical data with cis DDP + irradiation in advanced TCC are encouraging.

• Research Organization: Univ. of Tennessee, Memphis
• OSTI ID: 5331837
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLADDER
BODY
CARCINOMAS
COBALT 60
COBALT ISOTOPES
COMPLEXES
DATA
DATA FORMS
DIMENSIONS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
ENDOXAN
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
GROWTH
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LOCAL IRRADIATION
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
PLATINUM COMPLEXES
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RODENTS
TIME DEPENDENCE
TRANSITION ELEMENT COMPLEXES
TUMOR CELLS
URINARY TRACT
VERTEBRATES
YEARS LIVING RADIOISOTOPES