Preliminary report of a cooperative randomized study for the treatment of localized small cell lung carcinoma

Conference · Sat Sep 01 00:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5339685

Seydel, H G ^[1]; Creech, R H; Mietlowski, W L; Perez, C A

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1. Thomas Jefferson University Hospital, Philadelphia, PA

An analysis of 171 of 222 entered patients with localized small cell lung cancer after randomization to four treatment arms has been carried out. All patients received radiation therapy (4500 rad to the primary tumor and draining lymph nodes). One group of patients received no other treatment; the second group received cyclophosphamide (CY) during radiation therapy and CY and CCNU following radiation therapy; the third group received prophylactic brain irradiation (3000 rad in 10 fractions); and the fourth group received both prophylactic CY and CCNU as well as brain irradiation. Patients who did not receive CY and CCNU initially were treated upon relapse with the same CY/CCNU regimen. There is a significant difference in the incidence of brain metastases between the arms containing prophylactic brain irradiation or treatment at time of recurrence. The difference in brain metastases following prophylactic chemotherapy or chemotherapy at time of recurrence is of borderline significance. All treatment arms remain coded, but 17 to 19% of patients in each treatment arm had local and 43 to 52% had distant relapse. Two percent of patients had severe esophagitis and pneumonitis related to the radiation therapy regimen. Twenty to 24% of the patients in the chemotherapy groups have had severe bone marrow and GI toxicity. No patients have died of treatment-related toxicity. Patients with complete responses have a significantly longer median survival than those with partial or no responses.

• OSTI ID: 5339685
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:9; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
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DRUGS
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EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
INFLAMMATION
INFORMATION
IRRADIATION
ISOLATED VALUES
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PNEUMONITIS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY
TISSUES