Potential for boron neutron capture enhancement of Cf-252 brachytherapy treatment of localized tumors

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Nucl. Sci. Appl.; (United States)

OSTI ID:6707953

Schroy, C B; Beach, J L; Goud, S N; Feola, J M; Maruyama, Y; Blue, J W

Cultured Chinese hamster cells were irradiated with californium-252 neutrons and gamma rays at dose rates of 148 cGy/h and 68 cGy/h, respectively. Survival curves were obtained with and without 60 ..mu..g/ml of boron-10 in the culture medium. When the data were fitted to the linear-quadratic model of cell survival it was found that boron increased ..cap alpha.. (the 'single-hit' parameter) by 32% and decreased ..beta.. (the ''double-hit'' parameter) by 8%. The ..cap alpha../..beta.. ratio increased to 4.34 Gy in the presence of boron from 3.03 Gy in its absence. This translated to an 8% reduction in californium dose needed to effect 10% cell survival. It is concluded that there may be a sufficiently high thermal neutron fluence present during californium brachytherapy for boron-neutron capture dose augmentation to be feasible. Treatment of inoperable solid local tumors would be of possible benefit.

• Research Organization: Cleveland Clinic Foundation, Dept. of Radiation Therapy, Cleveland, OH 44106
• OSTI ID: 6707953
• Journal Information: Nucl. Sci. Appl.; (United States), Journal Name: Nucl. Sci. Appl.; (United States) Vol. 2:3; ISSN NSAPD
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BIOLOGICAL RADIATION EFFECTS
BORON 10
BORON ISOTOPES
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CHO CELLS
CULTURE MEDIA
DATA ANALYSIS
DISEASES
DOSE RATES
ELECTROMAGNETIC RADIATION
EMISSION
EVEN-EVEN NUCLEI
GAMMA RADIATION
HAMSTERS
HEAVY NUCLEI
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEDICINE
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON EMISSION
NEUTRON FLUENCE
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
PHOTON EMISSION
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
STABLE ISOTOPES
SURVIVAL CURVES
THERAPEUTIC USES
THERAPY
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES