Complications of Cf-252 neutron brachytherapy: Review of reported experiences

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Nucl. Sci. Appl.; (United States)

OSTI ID:6698805

Kal, H B

Californium-252, an isotope emitting neutrons, gamma photons and alpha particles, is investigated for its practical use in brachytherapy. In the early seventies results of experiments with californium neutrons on a variety of biological systems became available. Based on experiments with Chinese hamster cells in the very low dose rate region, an author suggested as an interim guideline, that 60 Gy of radium gamma rays in 7 days is equivalent to 8.9 Gy of Cf-neutrons. An RBE value of 6.7 at a Cf dose rate of about 0.1 Gy/h was suggested. Results of clinical trials with Cf-neutrons with respect to local control rate and complication rate are reviewed and compared with results of clinical trials with neutrons produced by cyclotrons and other generators and applied as external radiation to the patients.

• Research Organization: Radiobiological Institute TNO, Rijswijk
• OSTI ID: 6698805
• Journal Information: Nucl. Sci. Appl.; (United States), Journal Name: Nucl. Sci. Appl.; (United States) Vol. 2:3; ISSN NSAPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ACCELERATORS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH METALS
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
ANIMAL CELLS
ANIMALS
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CHARGED PARTICLES
CHO CELLS
CYCLIC ACCELERATORS
CYCLOTRONS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTS
EMISSION
EVEN-EVEN NUCLEI
GAMMA RADIATION
HAMSTERS
HEAVY NUCLEI
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LOW DOSE IRRADIATION
MAMMALS
MEDICINE
METALS
NEOPLASMS
NEUTRON EMISSION
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
PATIENTS
PHOTON EMISSION
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RADIUM
RBE
RESEARCH PROGRAMS
RODENTS
THERAPEUTIC USES
THERAPY
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES