Combined radiosensitization and radioprotection for oral cavity tumors: study with an oral cavity tumor model
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Adjuvant therapy with combined radioprotectors and radiosensitizers has not been extensively examined. We investigated the use of combined S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR-2721), misonidazole (Ro-07-0582) and single dose radiotherapy in treating the EMT 6/Ky tumor implanted in the buccal mucosa of Balb/c mice. Our results demonstrate that single dose irradiation plus WR-2721 or misonidazole prolonged the mean survival time (MST) of EMT 6/Ky bearing Balb/c mice significantly compared to either controls or single dose irradiation plus WR-2721 and misonidazole.
- Research Organization:
- Univ. of Kentucky Medical Center, Lexington
- OSTI ID:
- 6704077
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:3/4; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL MODELS
BODY
BODY AREAS
DIGESTIVE SYSTEM
DRUGS
EXPERIMENTAL NEOPLASMS
HEAD
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MAMMALS
MEDICINE
MEMBRANES
MICE
MISONIDAZOLE
MUCOUS MEMBRANES
NECK
NUCLEAR MEDICINE
ORAL CAVITY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATIONS
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RODENTS
SURVIVAL TIME
THERAPY
THIOIC ACIDS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL MODELS
BODY
BODY AREAS
DIGESTIVE SYSTEM
DRUGS
EXPERIMENTAL NEOPLASMS
HEAD
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MAMMALS
MEDICINE
MEMBRANES
MICE
MISONIDAZOLE
MUCOUS MEMBRANES
NECK
NUCLEAR MEDICINE
ORAL CAVITY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATIONS
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RODENTS
SURVIVAL TIME
THERAPY
THIOIC ACIDS
VERTEBRATES