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Radioprotection combined with hypoxic sensitization during radiotherapy of a solid; murine tumor

Journal Article · · Radiology; (United States)
; ;

EMT6 tumors were transplanted intramuscularly in the right hind leg of female BALC/c mice and irradiated when they reached a diameter of 6 to 7 mm. Each mouse received an intraperitoneal injection of WR-2721, misonidazole, or both prior to irradiation, and the dose needed to control half of the tumors at 30 days (TCD/sub 50/30/) was recorded. WR-2721 offered slight tumor protection, with a dose-modifying factor (DMF) of 1.04 to 1.15 for radioprotector doses of 150 to 500 mg/kg. Pretreatment with misonidazole at doses of 300 to 900 mg/kg yielded tumor sensitization with a DMF of 0.71 to 0.92. Pretreatment with both WR-2721 and misonidazole gave overall tumor sensitization with a DMF of 0.78 to 0.97. Possible combinations of sensitizers and protectors, while providing overall tumor sensitization, do not seem to improve the therapeutic ratio over what could be obtained from a sensitizer or protector along.

Research Organization:
Univ. of Kentucky, Lexington
OSTI ID:
5815879
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 148:1; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
HARD X RADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MAMMALS
MEDICINE
MICE
MISONIDAZOLE
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RODENTS
THERAPY
THIOIC ACIDS
VERTEBRATES
X RADIATION