Localization of /sup 3/H-estradiol in the reproductive organs of male and female baboons
The uptake and retention of radiolabeled estradiol by both the male and female reproductive organs were examined in the baboon. Two male and two female baboons were injected intracardially with 1 microgram/kg body weight of /sup 3/H-estradiol and two animals, one male and one female, were injected with both labeled and 100 micrograms/kg body weight of unlabeled estradiol. One and a half hours after the injections, the animals were sacrificed and the uterus, cervix, vagina, oviduct, seminal vesicles, and prostate gland were removed and processed for autoradiography. The stratified squamous epithelia of the cervix and vagina demonstrated a light uptake of the label in the germinative, but not in the superficial cell layers. The columnar cells lining the oviduct and uterine glands were labeled, whereas the luminal epithelium of the uterus and the glandular epithelia of the seminal vesicles and prostate gland did not sequester the tritiated steroid. The interstitial cells of all the organs studied demonstrated a moderate to heavy uptake of the radioactivity, whereas the smooth muscle cells were lightly labeled except in the vagina, in which these cells displayed a moderate number of silver grains.
- Research Organization:
- Department of Anatomy, The University of Texas Health Science Center at San Antonio
- OSTI ID:
- 6703727
- Journal Information:
- J. Morphol.; (United States), Journal Name: J. Morphol.; (United States) Vol. 172:2; ISSN JOMOA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
APES
AUTORADIOGRAPHY
BIOCHEMISTRY
BODY
CHEMISTRY
DISTRIBUTION
ESTRADIOL
ESTRANES
ESTROGENS
FEMALE GENITALS
HORMONES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MALE GENITALS
MAMMALS
MORPHOLOGY
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
PRIMATES
RETENTION
STEROID HORMONES
STEROIDS
TISSUE DISTRIBUTION
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES