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Pharmacokinetics of the monoclonal antibody B72. 3 and its fragments labeled with either /sup 125/I or /sup 111/In

Journal Article · · Cancer Res.; (United States)
OSTI ID:6702939
; ; ; ; ; ;
A comparison of the pharmacokinetics of intact B72.3 (a murine monoclonal antibody specific for human breast and colon carcinoma) with F(ab')2 and Fab fragments labeled with /sup 111/In and /sup 125/I was done in athymic mice bearing target (LS174T) and non-target (HCT-15) tumors. IgG B72.3 labeled with either isotype imaged LS174T. Biodistributions of both labels were similar in all organs except liver. F(ab')2 also imaged the LS174T tumor, while Fab bearing either isotype did not. The blood clearance was Fab greater than F(ab')2 greater than immunoglobulin G B72.3 for both isotopes. /sup 111/In-labeled fragments yielded large accumulations in the kidneys which persisted for 2 days. The different patterns of biodistribution for the various forms of B72.3 labeled with the two isotopes suggest that the most desirable combination of fragment and isotope will depend on the intended use.
Research Organization:
E. I. duPont de Nemours, Co., Inc., North Billerica, MA
OSTI ID:
6702939
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 4; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
GASTROINTESTINAL TRACT
GLANDS
HYDROLASES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE 125
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LARGE INTESTINE
MAMMALS
MAMMARY GLANDS
MICE
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PAPAIN
PEPTIDE HYDROLASES
RADIOISOTOPES
RODENTS
SH-PROTEINASES
TISSUE DISTRIBUTION
USES
VERTEBRATES