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Comparative biodistributions of yttrium- and indium-labeled monoclonal antibody B72. 3 in athymic mice bearing human colon carcinoma xenografts

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5997434
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The biodistribution of yttrium- and indium-labeled monoclonal antibody (MAb) B72.3 IgG using three different chelate conjugates (SCN-Bz-EDTA, CA-DTPA, and SCN-Bz-DTPA) was compared in athymic mice bearing LS-174T tumors. The /sup 88/Y-SCN-Bz-DTPA-B72.3 yielded 40% ID/g at 5-7 days in the tumors, while the /sup 88/Y-SCN-Bz-EDTA-B72.3 and /sup 88/Y-CA-DTPA-B72.3 showed only 6-8% ID/g. The yttrium uptake in the bone with the SCN-Bz-EDTA and CA-DTPA conjugated IgG was over 14 and 11% ID/g, respectively, while /sup 88/Y-SCN-Bz-DTPA-B72.3 showed only 3% ID/g. In contrast, the /sup 111/In-labeled B72.3 uptake in the bone with all three chelate conjugates was 2-3% ID/g. The differences in yttrium- versus indium-labeled MAb biodistributions demonstrate the difficulty in using /sup 111/In-labeled MAbs to predict the biodistribution and dosimetry of /sup 90/Y-labeled MAbs unless chelate conjugates such as SCN-Bz-DTPA are used.

Research Organization:
National Cancer Institute, Bethesda, MD (USA)
OSTI ID:
5997434
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 30:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARCINOMAS
CHELATING AGENTS
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSIMETRY
DRUGS
DTPA
EDTA
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL NEOPLASMS
GASTROINTESTINAL TRACT
GLOBULINS
HOURS LIVING RADIOISOTOPES
IMMUNOGLOBULINS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LARGE INTESTINE
MAMMALS
MAN
MICE
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RODENTS
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES
YTTRIUM 90
YTTRIUM ISOTOPES