Effect of radiation therapy and in vitro x-ray exposure on lymphocyte subpopulations and their functions

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Am. J. Clin. Oncol.; (United States)

DOI:https://doi.org/10.1097/00000421-198204000-00069· OSTI ID:6702876

Wasserman, J; Blomgren, H; Petrini, B; Baral, E; Strender, L E; Jarstrand, C; von Stedingk, L V

Radiation treatment of breast cancer patients (45.0 Gy) profoundly affected the peripheral blood lymphocytes. The number of these cells was markedly reduced with non-T-cells being more extensively depleted than T-cells immediately after radiation. The long-lasting lymphopenia, on the other hand, was mainly due to reduced number of T-cells. Antigen and mitogen stimulability, MLC reactivity, pokeweed (PWM)-induced immunoglobulin (Ig) production in vitro, and different cytotoxic functions decreased. Depletion of lymphocytes largely restored the radiation-depressed lymphocyte reactivity. The effects of in vitro exposure of blood lymphocytes to x-rays were similar to those seen after radiotherapy. Non-T-cells and T-cells with Fc-receptors for IgG were relatively radiosensitive. This latter observation agreed well with demonstrated increase of PWM-induced Ig synthesis after in vitro exposure to x-rays. T-suppressor cells defined by monoclonal antibodies were, however, radioresistant. The cytotoxic functions were reduced. No correlations were found between the pretreatment immunological status or the extent of radiation-induced immunological suppression, respectively, and prognosis.

• Research Organization: Central Microbiological Laboratory, Stockholm, Sweden
• OSTI ID: 6702876
• Journal Information: Am. J. Clin. Oncol.; (United States), Journal Name: Am. J. Clin. Oncol.; (United States) Vol. 5:2; ISSN AJCOD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARCINOMAS
CONNECTIVE TISSUE CELLS
DISEASES
DYNAMIC FUNCTION STUDIES
ELECTROMAGNETIC RADIATION
GLANDS
IMMUNE REACTIONS
IN VITRO
IN VIVO
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMARY GLANDS
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SOMATIC CELLS
THERAPY
X RADIATION