Ferrioxamine excretion in iron-loaded man
Journal Article
·
· Blood; (United States)
OSTI ID:6701993
- Univ. of Washington, Seattle
Factors affecting iron excretion after subcutaneous desferrioxamine infusion were evaluated in individuals with iron overload. Urinary iron varied directly, whereas stool iron varied inversely with the level of erythropoiesis. Ascorbic acid greatly enhanced urinary iron excretion but had a less constant effect on stool iron. Stool iron losses contributed a greater proportion of total iron excretion at higher chelator dosage. These studies indicate the importance of biliary iron excretion in monitoring the effectiveness of desferrioxamine. They also suggest that large chelator doses may remove established iron overload much more rapidly than has previously been realized.
- OSTI ID:
- 6701993
- Journal Information:
- Blood; (United States), Journal Name: Blood; (United States) Vol. 60:2; ISSN BLOOA
- Country of Publication:
- United States
- Language:
- English
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560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANEMIAS
ASCORBIC ACID
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD FORMATION
BODY FLUIDS
CHELATING AGENTS
CLEARANCE
DEFEROXAMINE
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ERYTHROPOIESIS
EXCRETION
FECES
HEMIC DISEASES
IRON
MATERIALS
METALS
ORGANIC COMPOUNDS
PATIENTS
SYMPTOMS
THALASSEMIA
TRANSITION ELEMENTS
URINE
VITAMINS
WASTES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANEMIAS
ASCORBIC ACID
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD FORMATION
BODY FLUIDS
CHELATING AGENTS
CLEARANCE
DEFEROXAMINE
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ERYTHROPOIESIS
EXCRETION
FECES
HEMIC DISEASES
IRON
MATERIALS
METALS
ORGANIC COMPOUNDS
PATIENTS
SYMPTOMS
THALASSEMIA
TRANSITION ELEMENTS
URINE
VITAMINS
WASTES