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Effects of L-cysteine, L-cysteine derivatives and ascorbic acid on lead excretion in rats

Journal Article · · Res. Commun. Chem. Pathol. Pharmacol.; (United States)
OSTI ID:6743938
; ; ;
Urinary and fecal excretion of lead in rats was compared after intravenous administration of L-cysteine and a number of its derivatives. In terms of increasing total lead excretion, L-cysteine ethyl ester was about half as effective as D-penicillamine, whereas L-cysteine and all other derivatives tested were only marginally effective. Interestingly, L-cysteine ethyl ester appeared to increase lead depletion mainly through biliary excretion. This compound may, therefore, have lower renal toxicity than other chelating agents which promote lead excretion principally by increasing urinary elimination. Dietary supplements containing 1 percent cysteine, 1 percent ascorbic acid or 1 percent of both substances did not dramatically increase lead elimination. Other derivatives of L-cysteine, viz., L-cysteine methyl ester, N-acetylcysteine and D-cysteine did not offer any advantage over L-cysteine in enhancing lead excretion. Dietary supplements of 1 percent L-cysteine and ascorbic acid, either individually or in combination, did not appear to increase total lead excretion dramatically.
Research Organization:
State Univ. of New York, Buffalo
OSTI ID:
6743938
Journal Information:
Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 20:1; ISSN RCOCB
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
550500* -- Metabolism
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
ASCORBIC ACID
BILE
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATES
CHELATING AGENTS
CLEARANCE
COMPLEXES
CYSTEINE
DIET
DRUGS
ELEMENTS
EXCRETION
FECES
IN VIVO
INJECTION
INTAKE
INTRAVENOUS INJECTION
KIDNEYS
LEAD
MAMMALS
METABOLISM
METALS
MOLECULAR STRUCTURE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PENICILLAMINE
RADIOPROTECTIVE SUBSTANCES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
THIOLS
URINE
VERTEBRATES
VITAMINS
WASTES