Mechanism of in vivo iron chelation by pyridoxal isonicotinoyl hydrazone and other imino derivatives of pyridoxal. [Rats]

Journal Article · Wed Jul 01 04:00:00 EDT 1981 · J. Lab. Clin. Med.; (United States)

OSTI ID:5525682

Hershko, C; Avramovici-Grisaru, S; Link, G; Gelfand, L; Sarel, S

The source of iron chelated in vivo by the new iron-chelating agent PIH and its mechanism of excretion have been studied in normal and hypertransfused rats. PIH is able to chelate iron from both parenchymal and RE iron stores. Unlike DF, which promotes both urinary and fecal iron excretion, in this model PIH-induced iron excretion is limited almost entirely to the gut. Response to PIH is directly related to dosage, and oral doses ranging from 125 to 500 mg/kg/day are well tolerated. Six additional imino derivatives of pyridoxal have been studied, but none of these new compounds was as effective as PIH. Our study indicates that oral PIH is comparable in efficiency with parenteral DF and is of potential usefulness in the management of iron overload.

• OSTI ID: 5525682
• Journal Information: J. Lab. Clin. Med.; (United States), Journal Name: J. Lab. Clin. Med.; (United States) Vol. 98:1; ISSN JLCMA
• Country of Publication: United States
• Language: English

Related Subjects

551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
AZINES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CHELATING AGENTS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
FECES
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
IN VIVO
INTESTINES
IRON
MAMMALS
MATERIALS
METALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHYSIOLOGY
PYRIDINES
PYRIDOXAL
RATS
RODENTS
TRANSITION ELEMENTS
URINE
VERTEBRATES
WASTES