Total bone calcium in normal women: effect of age and menopause status

Journal Article · Tue Dec 01 04:00:00 EST 1987 · J. Bone Miner. Res.; (United States)

DOI:https://doi.org/10.1002/jbmr.5650020605· OSTI ID:6701909

Gallagher, J C; Goldgar, D; Moy, A

Bone density in different regions of the skeleton was measured in 392 normal women aged 20-80 years by dual photon absorpiometry. In premenopausal women, aged 25-50 years, multiple regression analysis of regional bone density on age, height, and weight showed a small significant decrease in total bone density (less than 0.01) but no significant change in other regions of the skeleton. In postmenopausal women there were highly significant decreases in all regions of the skeleton (p less than 0.001), and bone density in these areas decreased as a logarithmic function of years since menopause. Based on multiple regression analyses, the decrease in spine density and total bone calcium was 2.5-3.0 times greater in the 25 years after menopause than the 25 years before menopause. The largest change, however, occurred in the first five years after menopause. During this time the estimated annual change in spine density and total bone calcium was about 10 times greater than that in the premenopausal period. These results demonstrate the important effect of the menopause in determining bone mass in later life.

• Research Organization: Creighton Univ. School of Medicine, Omaha, NB (USA)
• OSTI ID: 6701909
• Journal Information: J. Bone Miner. Res.; (United States), Journal Name: J. Bone Miner. Res.; (United States) Vol. 2:6; ISSN JBMAR
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
ALKALINE EARTH METALS
BODY
BODY COMPOSITION
CALCIUM
COMPUTERIZED TOMOGRAPHY
DENSITY
DIAGNOSTIC TECHNIQUES
ELEMENTS
EMISSION COMPUTED TOMOGRAPHY
GADOLINIUM ISOTOPES
ISOTOPES
MATHEMATICS
MENOPAUSE
METALS
ORGANS
PHYSICAL PROPERTIES
RARE EARTH ISOTOPES
REGRESSION ANALYSIS
SKELETON
STATISTICS
TOMOGRAPHY