Synthesis and phosphorylation of histone H1 and high mobility group proteins in the regenerating rat liver after X irradiation
Journal Article
·
· Radiat. Res.; (United States)
A rat was irradiated to the upper abdomen including the liver and then partially hepatectomized. The subsequent synthesis and phosphorylation of histone H1 and nonhistone chromosomal high mobility group (HMG) proteins were investigated. Incorporation of (/sup 3/H)lysine into histone H1 was increased and reached its peak at 27 h after hepatectomy, and 14 Gy of X rays inhibited the increase. Increase in the incorporation of (/sup 3/H)lysine into HMG (1 + 2), 14, and 17 which occurred around 27 h after hepatectomy was not inhibited by 14 Gy irradiation. Phosphorylation of histone H1, measured with 32Pi incorporation in vivo, was maximal between 21 and 24 h, and it was inhibited by 4.8 Gy of X rays and delayed with 1.9 Gy. Phosphorylation of HMG 14, which was the only HMG protein phosphorylated under present conditions, was not affected by X irradiation. The (/sup 3/H)thymidine incorporation into nuclear DNA started increasing at 21 h and reached its maximum at 27 h after hepatectomy. X irradiation with 4.8 Gy inhibited the incorporation, and 1.9 Gy lowered it.
- Research Organization:
- National Institute of Radiological Sciences, Chiba-shi, Japan
- OSTI ID:
- 6700406
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BODY AREAS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DIGESTIVE SYSTEM
DNA
ELECTROMAGNETIC RADIATION
GLANDS
HISTONES
IONIZING RADIATIONS
LABELLED COMPOUNDS
LIVER
LYSINE
MAMMALS
NUCLEIC ACIDS
NUCLEOPROTEINS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHOSPHORYLATION
PROTEINS
RADIATION EFFECTS
RADIATIONS
RATS
RECOVERY
RODENTS
TRITIUM COMPOUNDS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BODY AREAS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DIGESTIVE SYSTEM
DNA
ELECTROMAGNETIC RADIATION
GLANDS
HISTONES
IONIZING RADIATIONS
LABELLED COMPOUNDS
LIVER
LYSINE
MAMMALS
NUCLEIC ACIDS
NUCLEOPROTEINS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHOSPHORYLATION
PROTEINS
RADIATION EFFECTS
RADIATIONS
RATS
RECOVERY
RODENTS
TRITIUM COMPOUNDS
VERTEBRATES
X RADIATION