Effects of Irradiation on the Incorporation of Amino-Acid into Normal and Regenerating Rat Liver
A comparison of the effects of x rays on the potential capabilities of livers of normal and partially hepatectomized rats to incorporate amino acids into liver porteins in relation to the dose and time of exposure to radiation after hepatectomy is presented. The intact rat liver differs qualitatively from the hepatic tissue remaining after partial hepatectomy as far as the effect of x irradiation on the incorporation of leucine-U-C/sup 14/ into liver proteins is concerned. Thus, x irradiation at 1000 or 2000 r is followed by an increase in the isotope concentration in the proteins of the nonhepatectomized rat liver, whereas in the case of regenerating liver exposed to 1000 r, a decrease in the isotope concentration in liver proteins is found if the animals are irradiated within 6 hr after hepatectomy. After this time period, the exposure of the hepatectomized rats to x rays is without effect on amino acid incorporation. It is concluded that the normal rat liver, with cells in the intermitotic phase, and regenerating liver, many cells of which are in the pre-mitotic phase, seem to respond differently to the action of ionizing radiation as far as their ability to incorporate C/sup 14/ labeled leucine into protein is concerned.
- Research Organization:
- Univ. of Rochester School of Medicine, Rochester, N.Y.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-000070
- OSTI ID:
- 4823712
- Journal Information:
- Nature (London), Journal Name: Nature (London) Journal Issue: 4798 Vol. 192; ISSN 0028-0836
- Publisher:
- Nature Publishing Group
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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