Effect of irradiation on amino acid in vitro incorporation in the course of liver regeneration
The in vitro incorporation of/sup 14/C-leucine by rat liver microsomes is studied under four different physiological states: normal liver of adult rats; liver irradiated with 4,000 rads of /sup 6o/Co gamma rays; liver after partial hepatectomy; and regenerating liver in preirradiated rats 2, 5, 12, and 24 hrs after treatment. Both irradiation and partial hepatectomy, when applied separately, stimulate the endogenous activity of microsomes, whereas pre- irradiation abolishes the stimulatory effect in the early hours after partial hepatectomy. The results are in agreement with the concept that irradiation stimulates the operating synthetic program of the ce1l and inhlbits cellular reprogramming. (GE)
- Research Organization:
- Central Biochemistry Lab., Sofia
- NSA Number:
- NSA-29-000709
- OSTI ID:
- 4420412
- Journal Information:
- Z. Naturforsch., c, v. 28c, no. 5-6, pp. 313-315, Journal Name: Z. Naturforsch., c, v. 28c, no. 5-6, pp. 313-315; ISSN ZNFCA
- Country of Publication:
- Germany
- Language:
- English
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