Assessment of liver regeneration in the rat using the gamma camera

Journal Article · Mon Dec 31 23:00:00 EST 1973 · J. Nucl. Med., v. 15, no. 1, pp. 10-16

OSTI ID:4325558

Karran, S J; Leach, K G; Blumgart, L H

A method of imaging the liver of the rat using a pinhole collimator and a gamma camera is described. The method allows imaging or other ongans in small animals. Radioisotopic scintigraphs of the rat liver using /sup 99m/Tc-sulfur colloid and /sup 75/Se-Lselenomethionine were obtained before and at intervals after partial hepatectomy. The sizes of the scintigraphs of the two compounds were closely similar and there was no obvious difference in their distribution within the liver, either before or at any time after partial hepatectomy. A close correlation was found between the mean area of the interal scintigraphs of the liver and liver weight (r = 0.95), and a formula was derived whereby liver weight could be calculated from the size of the scintigraphs. Following two- thirds partial hepatectomy in the rat the remnant was found to regain its normal mass within 7 to 10 days. The results support the use of technetium-sulfur colloid in the clinical assessment of liver regeneration after hepatectomy. (auth)

• Research Organization: Welsh National School of Medicine, Cardiff
• NSA Number: NSA-29-021282
• OSTI ID: 4325558
• Journal Information: J. Nucl. Med., v. 15, no. 1, pp. 10-16, Journal Name: J. Nucl. Med., v. 15, no. 1, pp. 10-16; ISSN JNMEA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*LIVER-- SCINTISCANNING
BIOLOGICAL REGENERATION
GAMMA CAMERAS
HEPATECTOMY
ISOMERIC NUCLEI
LABELLED COMPOUNDS
MASS
METHIONINE
N48830* --Life Sciences--New Tracer Techniques--Other
NUCLEAR MEDICINE
RADIOCOLLOIDS
RADIONUCLIDE ADMINISTRATION
RATS
RESEARCH PROGRAMS
SELENIUM 75
SELENIUM COMPOUNDS
SULFUR COMPOUNDS
TECHNETIUM 99
UPTAKE