Inhalation toxicology of fog-oil obscurant. Final report, October 1981-February 1986

Technical Report · Mon Dec 01 04:00:00 EST 1986

OSTI ID:6699491

Grose, E C; Selgrade, M J; Davies, D W; Stead, A J

Sixty-day-old, male and female rats were exposed by inhalation to fog-oil smoke. Mortality, LC50, subacute, and subchronic studies were performed. Mortality studies showed fog-oil smoke to be 100% lethal at 11.0 mg/L, 95% lethal at 5.0 mg/L, 20% lethal at 1.0 mg/L, and 0% lethal at 0.1 mg/L after a 6-hour exposure. The observed LC50 of fog-oil smoke after a 3.5-hr exposure was 5.2 mg/L. In the subacute and subchronic studies, rats were exposed to air, 0.2-, 0.5-, or 1.5-mg/L fog oil smoke for 3.5 hr/day, 4 days/wk for either 4 of 13 wk. Both pulmonary and systemic effects were investigated one day after the exposure ceased. For one 13-wk exposure group, animals were also examined 4 wk after the exposure. Following the subacute 4-exposure to 1.5 mg/L, a multifocal pneumonitis was observed. Lung lavage had an elevated number of polymorphonuclear leukoctes (PMNs), alveolar macrophages, and lung weights was observed after exposure to 0.5 mg/L. Pulmonary-function tests revealed an increase in end expiratory volume (EEV) after 1.5mg/L. Systemic effects after the subacute exposure were minimal. A decrease in zoxazolamine-induced paralysis time was observed following both 0.5 and 1.5 mg/L; however, no effect on pentobarbital-induced sleeping time was observed. Behavioral studies were negative, as were clinical chemistries and immune function tests.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (USA). Inhalation Toxicology Div.
• OSTI ID: 6699491
• Report Number(s): AD-A-176106/3/XAB
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
COLLOIDS
DISEASES
DISPERSIONS
FEMALES
FLUIDS
FOG
GASES
INHALATION
INTAKE
MAMMALS
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
PHAGOCYTES
PNEUMONIA
RATS
RESIDUES
RESPIRATORY SYSTEM DISEASES
RETICULOENDOTHELIAL SYSTEM
RODENTS
SMOKES
SOLS
SOMATIC CELLS
TISSUES
TOXICITY
VERTEBRATES
WEIGHT