Pulmonary effects due to subchronic exposure to oil fog

Technical Report · Mon Jan 01 04:00:00 EST 1990

OSTI ID:6643544

Selgrade, M K; Hatch, G E; Grose, E C; Stead, A G; Miller, F J

Male rats were exposed to an oil fog generated by flash vaporization and subsequent condensation of lightweight lubricating oil. Exposures were for 3.5 h/d, 4d/wk for 13 wk, at concentrations of 1.5, 0.5, 0.2 or 0.0 mg/l (1500, 500, 200, and 0 mg/cu m) and a particle size of approximately 1 micro m (mass median aerodynamic diameter). A number of biologic endpoints were assessed the day after the last exposure and, in some cases, after a 4 wk recovery period. Effects of 1.5 mg/l on male and female rats were compared. Diffuse accumulation of macrophages in the alveoli was observed in all oil fog exposed groups. The degree of severity was concentration dependent. Histopathologic changes were more prominent in males than in females and represented the most notable gender-related differences. Histologic effects observed one day and 4 wk post exposure were similar. Minimal histopathologic changes and minimal increase in lavage fluid protein were the only effects observed at the 0.2 mg/l exposure level. There was a significant increase in lavage fluid protein, percent lavagable polymorphonuclear leukocytes and lung wet and dry weight following exposure to both 0.5 and 1.5 mg/l.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
• OSTI ID: 6643544
• Report Number(s): PB-90-245465/XAB; EPA--600/J-90/080
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
LAVAGE
LEUKOCYTES
LUBRICANTS
LUBRICATING OILS
LUNGS
MACROPHAGES
MAMMALS
MATERIALS
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PETROLEUM PRODUCTS
PHAGOCYTES
RATS
RESPIRATORY SYSTEM
RODENTS
SEX DEPENDENCE
SOMATIC CELLS
TOXICITY
VERTEBRATES