Pulmonary effects due to short-term exposure to oil fog

Journal Article · Thu Jan 01 04:00:00 EST 1987 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398709531010· OSTI ID:6532529

Selgrade, M K; Hatch, G E; Grose, E C; Illing, J W; Stead, A G; Miller, F J; Graham, J A; Stevens, M A; Hardisty, J F

Rats were exposed to an oil fog generated by flash vaporation and subsequent condensation of lightweight lubricating oil. Exposures were for 3.5 h/d, 4 d/wk, for 4 wk, at concentrations of 1.5, 0.5, or 0.0 mg/l and a particle size of approximately 1 micron. Samples of respiratory tissues were taken for histopathologic analyses, lavage fluid samples were collected, and pulmonary function measurements were made the day after the last exposure. An accumulation of macrophages within the alveolar lumen, an increase in lavage fluid protein content, and an increase in total cell content in lavage fluid due to an influx of polymorphonuclear leukocytes was noted in rats exposed at the 1.5-mg level. Also, for this exposure group there was an increase in lung wet and dry weight and an increase in end-expiratory volume, and pneumonitis was observed histopathologically in 4 of 10 male rats exposed. Pneumonitis was not observed among six female rats examined. Oil fog had no effect on total lung capacity, residual volume, vital capacity, lung compliance, or the distribution of ventilated air within the lung. Effects following exposure to 0.5 mg/l were limited to slight accumulation of macrophages in the alveolar lumen and an increase in the total cells in lavage fluid, which could not be attributed to an increase in any particular cell type.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC
• OSTI ID: 6532529
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 1-2; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020600* -- Petroleum-- Health & Safety
550900 -- Pathology
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DYNAMIC FUNCTION STUDIES
ENVIRONMENTAL EXPOSURE
ETIOLOGY
LAVAGE
LEUKOCYTES
LUBRICANTS
LUBRICATING OILS
LUNGS
MACROPHAGES
MAMMALS
MATERIALS
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PARTICLE SIZE
PETROLEUM PRODUCTS
PHAGOCYTES
PNEUMONITIS
POLLUTION
RATS
RESPIRATORY SYSTEM
RODENTS
SEX DEPENDENCE
SIZE
SOMATIC CELLS
TOXICITY
VERTEBRATES
WEATHER