Review of early Cf-252 trials and the Lexington experience
In the early Cf-252 brachytherapy trials, the M.D. Anderson Hospital, Churchill Hospital in Oxford, England and the Memorial Sloan-Kettering Cancer Center treated a total of 53 tumors in a similar number of patients in early Phase I trials. This group of patients had mostly metastatic, recurrent, persistent, or multiple metastatic tumors. Only 20 patients had primary tumors of which 8 were of skin origin. There were 3 melanomas/sarcomas which would do poorly regardless of therapy. The remaining tumors were of many different sites. Estimates of RBE were determined in relation to Ir-192 and indicated a value of 6.0-7.5. The early trials were terminated before any real assessment of efficacy of Cf therapy was possible. The fact that the trials were abandoned greatly hindered support for later trials. The Lexington, Kentucky trials have treated --500 patients of which 306 were primary tumors of the cervix, uterus, or vagina. These later experiences have been the basis of an emerging understanding of Cf-252 for cancer therapy.
- Research Organization:
- Radiation Therapy Oncology Center, Univ. of Kentucky Medical Center, Lexington, KY
- OSTI ID:
- 6698926
- Journal Information:
- Nucl. Sci. Appl.; (United States), Vol. 2:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Lexington studies of Cf-252 brachytherapy for advanced cervical and uterine cancer
Experience with and potential of Cf-252 therapy for other tumors: Lexington clinical trials
Related Subjects
CALIFORNIUM 252
THERAPEUTIC USES
MELANOMAS
RADIOTHERAPY
RESEARCH PROGRAMS
SARCOMAS
UTERUS
IRIDIUM 192
METASTASES
PATIENTS
PERFORMANCE TESTING
RBE
SKIN DISEASES
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CALIFORNIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
FEMALE GENITALS
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
TESTING
THERAPY
USES
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)