Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Comparative in vitro cytotoxicity of nickel oxides and nickel-copper oxides to rat, mouse, and dog pulmonary alveolar macrophages

Journal Article · · J. Toxicol. Environ. Health; (United States)
; ;
Metal oxides containing either Ni alone (NiO's) or both Ni and Cu (Ni-CuO's) are encountered during Ni refining. Six NiO compounds calcined at temperatures ranging from < 650 to 1045/sup 0/ and four Ni-CuO's containing from 6.9 to 28% Cu and 44 to 69% Ni were screened for their in vitro cytotoxicity to alveolar macrophages (AM). NiO's were less toxic to rat AM than were the Ni-CuO compounds. The toxicity of the Ni-CuO compounds increased with increasing Cu content and decreasing Ni content of the molecules, indicating that the toxicity was due to the Cu content of the molecules. AM obtained from beagle dogs, F344/N rats, and B6C3F/sub 1/ mice displayed the following species sensitivities: dog > rat approx. = mouse, with dog AM being most sensitive. The observed differences in species sensitivities correlated with differences in the phagocytic abilities of dog, rat, and mouse AM, with the ranking of phagocytic abilities of the AM in decreasing order of ability being dog > rat > mouse.
Research Organization:
Inhalation Toxicology Research Institute, Albuquerque, NM (USA)
DOE Contract Number:
AC04-76EV01013
OSTI ID:
6698282
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 24:3; ISSN JTEHD
Country of Publication:
United States
Language:
English

Similar Records

Comparative cytotoxicity of four nickel compounds to canine and rodent alveolar macrophages in vitro
Journal Article · Tue Dec 31 23:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States) · OSTI ID:5001468
Phagocytosis of particulate nickel compounds by rat peritoneal macrophages in vitro
Journal Article · Thu Dec 31 23:00:00 EST 1981 · Carcinogenesis (N.Y.); (United States) · OSTI ID:6563065
Characteristics of alveolar macrophages following the deposition of a low burden of iron oxide in the lung
Journal Article · Mon Dec 31 23:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States) · OSTI ID:5810182

Related Subjects

560300* -- Chemicals Metabolism &amp; Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BODY
CHALCOGENIDES
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
COPPER COMPOUNDS
COPPER OXIDES
DOGS
LUNGS
MACROPHAGES
MAMMALS
MICE
NICKEL COMPOUNDS
NICKEL OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHAGOCYTES
RATS
RESPIRATORY SYSTEM
RODENTS
SENSITIVITY
SOMATIC CELLS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES