Comparative toxicity of free ions and complexes of copper and amino acids to Candida utilis

Journal Article · Fri Jan 01 04:00:00 EST 1971 · Microbiology (Engl. Transl.); (United States)

OSTI ID:6698152

Avakyan, Z A

The toxicity of complexes formed by copper with glycine, aspartic and glutamic acids, arginine, and ornithine was studied on a medium whose organic components do not form complexes with copper. All copper was found to enter into a complex with amino acids at pH 7.0. At more acid pH values, Cu/sup 2 +/ ions are present in the medium along with copper complexes. The copper concentration which reduces the mean growth rate of Candida utilis by 50%, varies within a range of 0.02-0.05 mM for all amino acids tested (the copper: amino acid ratio being 1:2). Increasing the amino acid concentration in the medium reduces the toxicity of copper complexes. Changing the pH toward alkaline values also reduces the toxicity of copper-amino acid complexes. The factors are discussed which produce an identical effect when parameters such as pH and amino acid concentration are changed.

• Research Organization: M. V. Lomonosov Moscow State Univ. (USSR)
• OSTI ID: 6698152
• Journal Information: Microbiology (Engl. Transl.); (United States), Journal Name: Microbiology (Engl. Transl.); (United States) Vol. 40:3; ISSN MIBLA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
CANDIDA
CARBOXYLIC ACIDS
COMPLEXES
COPPER
ELEMENTS
FUNGI
GROWTH
INHIBITION
METALS
MICROORGANISMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PH VALUE
PLANTS
SENSITIVITY
TOXICITY
TRANSITION ELEMENTS
YEASTS