The response of mouse jejunal crypt cells to Cs-137 gamma rays and Cf-252 neutron irradiation

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Nucl. Sci. Appl.; (United States)

OSTI ID:6695662

Coffey, C W; Meece, D; Beach, J L

Male CD/sub 2/F/sub 1//HAP mice were exposed to similar doses from Cs-137 and Cf-252 linear source arrays using a ferris wheel irradiator. The Cs-137 ..gamma..-ray dose rate was 87.2 cGy/hr as determined by TLD dosimetry. A paired ionization chamber measurement technique was utilized to evaluate the Cf-252 dose rate; i.e. 14.4 cGy/hr neutron and 6.5 cGy/hr gamma rays (n/..gamma.. ratio = 2.22). Jejunal crypt scoring criteria followed those established by a previous study. These experiments show that RBE in small bowel was high using microcolony assay. Analysis of crypt survival curves yielded a RBE for Cf-252 neutrons of approximately 6.0 for small bowel in agreement with data reported by the earlier study.

• Research Organization: Dept. of Radiation Medicine, Radiation Therapy Oncology Center, Univ. of Kentucky Medical Center, Lexington, KY
• OSTI ID: 6695662
• Journal Information: Nucl. Sci. Appl.; (United States), Journal Name: Nucl. Sci. Appl.; (United States) Vol. 2:3; ISSN NSAPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
560162 -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALI METAL ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CESIUM 137
CESIUM ISOTOPES
CRYPT CELLS
DATA ANALYSIS
DIGESTIVE SYSTEM
DOSE RATES
DOSES
DOSIMETRY
ELECTROMAGNETIC RADIATION
EMISSION
EVEN-EVEN NUCLEI
GAMMA DOSIMETRY
GAMMA RADIATION
GASTROINTESTINAL TRACT
HEAVY NUCLEI
INTESTINES
IONIZATION CHAMBERS
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
MEASURING INSTRUMENTS
MEDICINE
MICE
NEUTRON DOSIMETRY
NEUTRON EMISSION
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION DETECTORS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RBE
RODENTS
SMALL INTESTINE
SOMATIC CELLS
SURVIVAL CURVES
THERAPY
THERMOLUMINESCENT DOSIMETRY
VERTEBRATES
YEARS LIVING RADIOISOTOPES