Response of lymphoid organs to low dose rate Cf-252, Cs-137 and acute Co-60

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Nucl. Sci. Appl.; (United States)

OSTI ID:6716487

Feola, J; Maruyama, Y; Magura, C; Hwang, H N

RBE of low dose rate (LDR) /sup 252/Cf radiation was studied for thymus using weight loss compared to unirradiated controls. These were compared against LDR /sup 137/Cs and acute /sup 60/Co effects. For thymus, biexponential dose response curves were noted for acute /sup 60/Co and LDR /sup 137/Cs irradiations. No dose rate effect was noted with /sup 137/Cs. D/sub 37/ for the first component D/sub 1/ was 109 cGy and for the second D/sub 2/ was 624 cGy for /sup 60/Co. Relative biological effectiveness (RBE) is a complex endpoint and was different for the low dose (sensitive) and high dose (resistant) responses and for /sup 252/Cf. RBE/sub n/ of the sensitive portion was 1.7 and for overall was 4.0. Spleen response was also determined for the 3 radiations. Biexponential dose-response curves were also observed for resting spleen to acute /sup 60/Co and LDR /sup 137/Cs radiation. D/sub 1/ = 285 cGy and D/sub 2/ = 1538 cGy for acute /sup 60/Co; D/sub 1/ = 205 cGy for /sup 137/Cs and indicated a dose rate effect = 1.04 for /sup 137/Cs. The LDR /sup 137/Cs was 1.3x more effective than acute /sup 60/Co for the sensitive response; it was 1.9 x greater for the resistant response. However, the response to /sup 252/Cf vs. /sup 137/Cs for the spleen indicated that there was a greater sensitivity to dose rate than to LET. RBE/sub n/ for /sup 252/Cf vs. /sup 137/Cs was 1.0. Stimulation of spleen growth after injection of Corynebacterium parvum allowed study of radiation effects of proliferating spleen cells at day 10. Acute /sup 60/Co and LDR /sup 137/Cs ..gamma..-rays had reduced effects compared to LDR /sup 252/Cf radiation and RBE was 4.0 vs. LDR /sup 137/Cs. RBE in lymphoid organs thus depended on organ, on assay and on resting/proliferating status.

• Research Organization: Radiation Medicine, Univ. of Kentucky Medical Center, Lexington, KY
• OSTI ID: 6716487
• Journal Information: Nucl. Sci. Appl.; (United States), Journal Name: Nucl. Sci. Appl.; (United States) Vol. 2:3; ISSN NSAPD
• Country of Publication: United States
• Language: English

Related Subjects

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALI METAL ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CESIUM 137
CESIUM ISOTOPES
COBALT 60
COBALT ISOTOPES
DIAGRAMS
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ENERGY TRANSFER
EVEN-EVEN NUCLEI
GAMMA RADIATION
GROWTH
HEAVY NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LET
LOW DOSE IRRADIATION
LYMPHATIC SYSTEM
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RBE
SOMATIC CELLS
SPLEEN
SPLEEN CELLS
STIMULATION
THYMUS
WEIGHT MEASUREMENT
YEARS LIVING RADIOISOTOPES