Relative biological effectiveness of low- and high-LET radiotherapy beams for jejunal crypt cell survival at low doses per fraction

Conference · Sun Jul 01 04:00:00 EDT 1979 · Radiology; (United States)

OSTI ID:6187121

Fu, K K; Phillips, T L; Heilbron, D C; Ross, G; Kane, L J

In order to determine the relative biological effectiveness (RBE) of various low- and high-LET radiotherapy beams at low doses, LAF1 mice were exposed to one dose and 10 equally fractionated doses of /sup 60/Co ..gamma.. rays, /sup 137/Cs ..gamma.. rays, 4-MeV x rays, 300-kVp x rays, helium ions in the plateau and Bragg-peak region, and 15-MeV neutrons; survival of jejunal crypt cells with the microcolony assay of Withers and Elkind was determined using /sup 60/Co as the standard. RBE values for the survial of 10 cells/circumference for 10 fractionated exposures (2.4 Gy (240 rad) per fraction of /sup 60/Co) were: 1.07 for /sup 137/Cs, 1.06 for 4-MeV x rays, 1.16 for 300-kVp x rays, 1.10 for helium ions in the plateau, 1.29 for helium ions in the peak, and 3.02 for 15-MeV neutrons. As LET increased, RBE increased with decrease of dose/fraction.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 6187121
• Conference Information: Journal Name: Radiology; (United States) Journal Volume: 132:1
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
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560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CESIUM 137
CESIUM ISOTOPES
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
CRYPT CELLS
DIGESTIVE SYSTEM
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENERGY RANGE
ENERGY TRANSFER
EXTERNAL IRRADIATION
FAST NEUTRONS
FERMIONS
FRACTIONATED IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
HADRONS
HELIUM IONS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINES
IONIZING RADIATIONS
IRRADIATION
IRRADIATION PROCEDURES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KEV RANGE
KEV RANGE 100-1000
LET
LOW DOSE IRRADIATION
MAMMALS
MEDICINE
MEV RANGE
MEV RANGE 01-10
MEV RANGE 10-100
MICE
MINUTES LIVING RADIOISOTOPES
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RBE
RODENTS
SMALL INTESTINE
SOMATIC CELLS
SURVIVAL CURVES
THERAPY
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION
YEARS LIVING RADIOISOTOPES