Effects of sodium nitrite on ultraviolet light-induced relaxation and ultraviolet light-dependent activation of guanylate cyclase in bovine mesenteric arteries
- Linkoeping Univ. (Sweden)
It was demonstrated that precontracted strips from different bovine mesenteric arteries showed variation in sensitivity to ultraviolet radiation (366 nm). Some strips relaxed when they were exposed to ultraviolet light, others showed no sensitivity at all and, finally, some showed contraction. However, all arteries relaxed when they were irradiated with UV-light in the presence of 10 microM NaNO{sub 2}. Ultraviolet radiation (366 nm) increased the activity of guanylate cyclase in crude homogenate from bovine mesenteric arteries by about 20-fold in the presence of NaNO{sub 2}, while UV-light in the absence of sodium nitrite had no effect on the guanylate cyclase activation. These results support the notion that nitrite may be essential for vascular smooth muscle relaxation by UV-light, possibly through the release of nitric oxide.
- OSTI ID:
- 6695029
- Journal Information:
- Biochemical and Biophysical Research Communications; (USA), Journal Name: Biochemical and Biophysical Research Communications; (USA) Vol. 169:1; ISSN BBRCA; ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Activation of cerebral guanylate cyclase by nitric oxide
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase
Related Subjects
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMALS
ARTERIES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CATTLE
CONTRACTION
CYCLASES
DOMESTIC ANIMALS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
LYASES
MAMMALS
MUSCLES
NITRITES
NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RUMINANTS
SODIUM COMPOUNDS
ULTRAVIOLET RADIATION
VERTEBRATES