Toxicologic interactions between ozone and bacterial endotoxin

Journal Article · Sun Feb 01 04:00:00 EST 1987 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(87)80007-5· OSTI ID:6693028

Peavy, D L; Fairchild, II, E J

The effects of acute exposure of mice to bacterial lipopolysaccharide (LPS), the endotoxin of gram negative microorganisms, and ozone (O3) have been investigated. Intraperitoneal (ip) administration of 5 mg/kg LPS to CD-1 mice followed by exposure to 15 ppm O3 for 1.5 hr produced synergistic effects as measured by pulmonary edemagenesis and lethality assays. In contrast, ip administration of 0.1-1.6 mg/kg LPS to CD-1 mice over 5 consecutive days, a dose regimen resulting in LPS tolerance, protected against a lethal challenge of 20 ppm O3 for 3 hr. A statistically significant increase in catalase and glutathione peroxidase activity was measured in homogenates of lungs obtained from CD-1 mice receiving a tolerance-inducing regimen of LPS. These results demonstrate that two, distinct toxicologic interactions can occur between O3 and bacterial LPS. Synergism between these agents could explain, in part, the increased susceptibility of O3-exposed animals to respiratory infection with gram negative microorganisms. Protection resulting from LPS-induced increases in pulmonary antioxidant activity provides additional evidence that O3 and, possibly, LPS mediate their toxicity through oxidative mechanisms.

• Research Organization: Univ. of Texas Health Science Center, Houston
• OSTI ID: 6693028
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGENS
ANTIOXIDANTS
BACTERIA
BACTERIAL DISEASES
CARBOHYDRATES
DISEASES
ENDOTOXINS
ESCHERICHIA COLI
INFECTIOUS DISEASES
INFECTIVITY
LIPIDS
LIPOPOLYSACCHARIDES
MAMMALS
MATERIALS
MICE
MICROORGANISMS
ORGANIC COMPOUNDS
OZONE
POLYSACCHARIDES
RODENTS
SACCHARIDES
SYNERGISM
TOXIC MATERIALS
TOXICITY
TOXINS
VERTEBRATES