Covalent binding of (/sup 14/C)thiourea to protein in lungs from endotoxin-treated rats
Journal Article
·
· Toxicol. Appl. Pharmacol.; (United States)
Administration of thiourea to mature male rats at a dosage of 3.5 mg/kg (ip) produced marked pleural effusion by 2 hr (3-4 ml). Pretreatment with bacterial lipopolysaccharide (endotoxin) significantly reduced this pleural effusion (less than 0.5 ml). Despite this unequivocal effect, there was no corresponding reduction in the covalent binding of (/sup 14/C)thiourea to lung protein. These data indicate that the protective effect of endotoxin against the initial stages of thiourea pneumotoxicity does not involve a reduction in binding of the (/sup 14/C)thiourea or a metabolite to lung protein. However, alterations in low levels of binding to specific cell types or particular protein(s) relative to covalent binding cannot be ruled out.
- Research Organization:
- Department of Pharmacology, School of Medicine, University of California, Davis
- OSTI ID:
- 5392333
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 70:1; ISSN TXAPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550901* -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGENS
ANTITHYROID DRUGS
BIOLOGICAL EFFECTS
BODY
CARBON 14 COMPOUNDS
CARBONIC ACID DERIVATIVES
DRUGS
ENDOTOXINS
HORMONE ANTAGONISTS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LUNGS
MALES
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PROTEINS
RATS
RESPIRATORY SYSTEM
RODENTS
THIOUREA
THIOUREAS
TOXIC MATERIALS
TOXICITY
TOXINS
TRACER TECHNIQUES
VERTEBRATES
551001 -- Physiological Systems-- Tracer Techniques
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGENS
ANTITHYROID DRUGS
BIOLOGICAL EFFECTS
BODY
CARBON 14 COMPOUNDS
CARBONIC ACID DERIVATIVES
DRUGS
ENDOTOXINS
HORMONE ANTAGONISTS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LUNGS
MALES
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PROTEINS
RATS
RESPIRATORY SYSTEM
RODENTS
THIOUREA
THIOUREAS
TOXIC MATERIALS
TOXICITY
TOXINS
TRACER TECHNIQUES
VERTEBRATES