Evaluation of 10 kits for determination of human choriogonadotropin in serum

Journal Article · Sat Oct 01 04:00:00 EDT 1983 · Clin. Chem. (Winston-Salem, N.C.); (United States)

OSTI ID:6681829

Rasor, J L; Farber, S; Braunstein, G D

A comparison was made of 10 commercially available radioimmunoassay kits (American Diagnostics, Becton Dickinson, BioGenex, Clinical Assays, Hybritech, Leeco, Mallinckrodt, Microanalytic, Nuclear Medical Systems, and Radioassay Systems) for determination of human choriogonadotropin (hCG), using serum pools, hCG CR119 (NIH), 2nd I.S. (who), and 1st I.R.P. (who). Criteria were ease of performance, total assay time, sensitivity, potency, and parallelism as compared with reference standards and results for 15 serum pools. The Mallinckrodt kit exhibited the best overall performance, with good low-concentration sensitivity, parallelism with two of the three reference preparations, and good clinical correlation as compared with the reference kit from NIH. Because the antibodies used in the kits are occasionally changed by the manufacturers, these results are necessarily valid only for kits that include reagents identical to those in the kits that we tested.

• OSTI ID: 6681829
• Journal Information: Clin. Chem. (Winston-Salem, N.C.); (United States), Journal Name: Clin. Chem. (Winston-Salem, N.C.); (United States) Vol. 29:10; ISSN CLCHA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD SERUM
COMPARATIVE EVALUATIONS
GONADOTROPINS
HCG
HORMONES
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOASSAY
RADIOIMMUNOASSAY
SENSITIVITY
TRACER TECHNIQUES