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Radiolabeled fibronectin for the scintigraphic detection of pulmonary emboli in dogs

Journal Article · · Invest. Radiol.; (United States)
; ; ; ; ;

Plasma fibronectin, a glycoprotein that is a component of blood thrombi, was evaluated for the in vivo scintigraphic detection of pulmonary emboli in dogs. Fibronectin (canine or human) was labeled with either /sup 131/I or with /sup 111/In and diethylenetriaminepenta-acetic acid (DTPA) as the bifunctional chelating agent using a modification of the mixed anhydride method. The radiolabeled proteins were administered intravenously 20 to 30 minutes after the embolization of a 99mTc-labeled thrombus. The uptake of radioactivity by the embolus was monitored scintigraphically up to 24 hours. At the end of each experiment, the animal was killed and in vitro tissue counting of radioactivity was performed. Comparative study of the /sup 131/I- and /sup 111/In-labeled agent is presented with particular reference to their pharmacokinetics. The in vivo uptake of radioactivity by the emboli was limited, indicating that radiolabeled fibronectin is not a good scintigraphic agent for the detection of pulmonary emboli.

Research Organization:
Yale Univ. School of Medicine, New Haven, CT (USA)
OSTI ID:
6681310
Journal Information:
Invest. Radiol.; (United States), Journal Name: Invest. Radiol.; (United States) Vol. 23:8; ISSN INVRA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOHYDRATES
CARBOXYLIC ACIDS
CHELATING AGENTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EVALUATION
GLUCOPROTEINS
GLYCOPROTEINS
HOURS LIVING RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLING
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM DISEASES
SACCHARIDES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES