Scintigraphic diagnosis of experimental pulmonary embolism with /sup 111/In-labeled platelets. [/sup 99m/Tc, dogs]
Stasis thrombi, radiolabeled with Tc-99m sulfur colloid, were produced in six dogs by the injection of human thrombin into isolated jugular vein segments. After release of the thrombi, scintigraphic images demonstrated 16 pulmonary emboli containing Tc-99m. Autologous platelets labeled by the In-111 oxine method were injected. Sequential images demonstrated platelet accumulation in 14 of the 16 emboli within 1 hr. The emboli were recovered at autopsy and their activity assayed. The mean uptake of In-111-labeled platelets was 1.1% dose/g of embolus, and the mean embolus-to-blood ratio was 16. Our results demonstrate that fresh pulmonary emboli in dogs can be detected by imaging with In-111-labeled platelets, and suggest that radiolabeled platelets may provide a simple, noninvasive method for the direct visualization of pulmonary emboli in patients.
- Research Organization:
- Edward Mallinckrodt Inst. of Radiology, St. Louis
- OSTI ID:
- 5335000
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 18:9; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY FLUIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EMBOLI
HOURS LIVING RADIOISOTOPES
IMAGES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLING
LUNGS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES