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1982 George Simon Memorial Fellowship Award. Experimental studies with /sup 111/In-labeled platelets in pulmonary embolism

Journal Article · · Invest. Radiol.; (United States)
OSTI ID:6492542
The effects of several potential modifiers on the detection of experimental pulmonary emboli by /sup 111/In-labeled autologous platelets were studied. Contrast material did not affect embolus visualization; heparin prevented it, but its effect was not irreversible. The addition of exogenous thrombin to the experimental thrombus was not necessary for successful detection of the resulting emboli. /sup 111/In-oxine detected a small number of emboli without in vitro platelet labeling. Acutely embolized thrombi up to 72 hours old were readily identified by labeled platelets, but emboli older than 24 hours were almost impossible to detect. There was evidence suggesting propagation of emboli within the pulmonary arteries.
Research Organization:
Yale University School of Medicine, Department of Diagnostic Radiology, New Haven, Connecticut
OSTI ID:
6492542
Journal Information:
Invest. Radiol.; (United States), Journal Name: Invest. Radiol.; (United States) Vol. 17:4; ISSN INVRA
Country of Publication:
United States
Language:
English