Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Technetium-labeled heparin: preliminary report of a new radiopharmaceutical with potential for imaging damaged coronary arteries and Cyocardium. [Dogs]

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6678430
Heparin has been labeled with (/sup 99m/Tc) pertechnetate and its ability to image damaged coronary vessels and myocardium during and following myocardial ischemia has been studied in experimental animals. The data obtained indicate that Tc-99m heparin localizes in damaged myocardium and coronary vessels in canine models of temporary myocardial ischemia and reperfusion and in damaged myocardium during fixed coronary occlusion. Scintigraphic detection of damaged myocardium was possible in both models, but the highest levels of Tc-99m heparin in damaged myocardial tissue were found in those dogs with temporary coronary occlusion and reflow. The data suggest that Tc-99m heparin may be of value as a positive imaging agent when coronary arteries or myocardium are injured and either reperfusion is allowed and/or significant blood flow persists in the damaged area.
Research Organization:
Univ. of Texas, Dallas
OSTI ID:
6678430
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:7; ISSN JNMEA
Country of Publication:
United States
Language:
English

Similar Records

Modified technetium-99m heparin for the imaging of acute experimental myocardial infarcts
Journal Article · Thu Jan 31 23:00:00 EST 1980 · J. Nucl. Med.; (United States) · OSTI ID:5371901

Quantification of myocardial injury produced by temporary coronary artery occlusion and reflow with technetium-99m-pyrophosphate
Journal Article · Sat Feb 28 23:00:00 EST 1987 · Circulation; (United States) · OSTI ID:6863040

Mechanisms contributing to myocardial accumulation of /sup 99m/Tc stannous pyrophosphate after coronary arterial occlusion. [Dogs, /sup 32/P]
Journal Article · Fri Dec 31 23:00:00 EST 1976 · Am. J. Cardiol.; (United States) · OSTI ID:7142926