Modified technetium-99m heparin for the imaging of acute experimental myocardial infarcts

Journal Article · Fri Feb 01 04:00:00 EST 1980 · J. Nucl. Med.; (United States)

OSTI ID:5371901

Kulkarni, P V; Parkey, R W; Wilson, III, J E; Lewis, S E; Buja, L M; Bonte, F J; Willerson, J T

We have reported previously that technetium-99m heparin (TcH) accumulates in, and allows scintigraphic identification of, damaged canine myocardium occurring with temporary occlusion and reperfusion of the left anterior descending (LAD) coronary artery. A recent modification consists of using heparin from sheep lung, with stannous phosphate as the reducing agent. In 12 dogs with permanent LAD occlusion, six were injected intravenously with TcH (3-6 mCi) at 24 hr after occlusion, and six at 48, hr. Each experimental animal demonstrated relatively high TcH uptake in the left-ventricular infarct region as compared with normal myocardium. The in vivo scintigrams in all animals with gross myocardial infarcts were positive. The results suggest that this modified TcH has value for identifying experimental myocardial infarcts and that reduced bone uptake, compared with that occuring with Tc-99m phosphates, may be an advantage for scintigraphic infarct detection.

• Research Organization: Univ. of Texas, Dallas
• OSTI ID: 5371901
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMALS
ANTICOAGULANTS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORONARIES
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DISTRIBUTION
DOGS
DRUGS
EXPERIMENTAL DATA
HEART
HEPARIN
HOURS LIVING RADIOISOTOPES
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MUCOPOLYSACCHARIDES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SACCHARIDES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES