Mechanisms contributing to myocardial accumulation of /sup 99m/Tc stannous pyrophosphate after coronary arterial occlusion. [Dogs, /sup 32/P]

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Am. J. Cardiol.; (United States)

DOI:https://doi.org/10.1016/S0002-9149(77)80011-8· OSTI ID:7142926

Coleman, R E; Klein, M S; Ahmed, S A; Weiss, E S; Buchholz, W M; Sobel, B E

The relation between the accumulation of pyrophosphate and technetium-99m in myocardium with reversible and irreversible ischemic injury was studied in dogs subjected to transitory or persistent coronary arterial occlusion. Among four dogs with coronary occlusion maintained for less than 20 minutes, none had either increased MB creatine kinase (CK) (the ''myocardial'' CK isoenzyme) activity serum or a positive /sup 99m/Tc stannous pyrophosphate image. Seven dogs with coronary occlusion maintained for 30 or more minutes had elevated serum MB CK activity, and five of the seven had positive (abnormal) images. Thus, although false negative images may occur occasionally despite myocardial damage, both increased serum MB CK and abnormal images generally accompanied prolonged coronary occlusion. In contrast, ischemia without infarction was not associated with abnormal images. Both /sup 99m/Tc and /sup 32/P labeled pyrophosphate were accumulated extensively and proportionally in myocardium from zones of infarction, and uptake of both tracers was comparable although modest in isolated mitochondria. Similar results were obtained after myocardial infarction in animals with induced profound leukopenia. Thus, phagocytosis of the radiopharmaceutical agent by leukocytes migrating into the infarct is not an essential mechanism accounting for uptake. These results indicate that abnormal images reflect uptake of pyrophosphate, associated with /sup 99m/Tc, by irreversibly injured myocardium rather than leukocytic infiltration involved in the inflammatory response in the heart.

• Research Organization: Washington Univ., St. Louis
• OSTI ID: 7142926
• Journal Information: Am. J. Cardiol.; (United States), Journal Name: Am. J. Cardiol.; (United States) Vol. 39:1; ISSN AJCDA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MITOCHONDRIA
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANOIDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS 32
PHOSPHORUS COMPOUNDS
PHOSPHORUS ISOTOPES
PYROPHOSPHATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES