Fatty acid transport into the brain
Technical Report
·
OSTI ID:6665733
Fifteen ..mu..c of 1-/sup 14/C palmitate was injected into three groups of rats. Group I served as control animals, group II animals were subjected to functional hepatectomy, and group III animals received the tracer by an intracarotid injection followed by decapitation fifteen seconds later. The circulating blood lipids in the control group had most of the radioactivity in the triglyceride fraction whereas in both hepatectomized and carotid injected rats the blood free fatty acid (FFA) fraction had most of the radioactivity. Under these conditions the uptake of radioactivity by the brain was about six times higher in hepatectomized animals and fourteen times higher in the intracarotid injected animals than in the control group. This indicates that FFA is a preferred form of fatty acid transport to the brain.
- Research Organization:
- California Univ., Los Angeles (USA). Lab. of Nuclear Medicine and Radiation Biology
- DOE Contract Number:
- AC03-76SF00012
- OSTI ID:
- 6665733
- Report Number(s):
- UCLA-12-839
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ARTERIES
BIOLOGICAL LOCALIZATION
BLOOD VESSELS
BODY
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CAROTID ARTERIES
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
HEPATECTOMY
HEXADECANOIC ACID
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MONOCARBOXYLIC ACIDS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RATS
RODENTS
SURGERY
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ARTERIES
BIOLOGICAL LOCALIZATION
BLOOD VESSELS
BODY
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CAROTID ARTERIES
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
HEPATECTOMY
HEXADECANOIC ACID
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MONOCARBOXYLIC ACIDS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RATS
RODENTS
SURGERY
TRACER TECHNIQUES
VERTEBRATES