Metabolism of linolenic acid in developing brain. I. Incorporation of radioactivity from 1-$sup 14$C linolenate into brain fatty acids

Journal Article · Wed Jan 01 04:00:00 EST 1975 · Lipids, v. 10, no. 4, pp. 238-241

OSTI ID:4102009

Dhopeshwarkar, G A; Subramanian, C

Twelve-thirteen day old rats were given 1-$sup 14$C linolenic acid by intraperitoneal injection. Fatty acids were isolated from the brains of animals sacrificed at the end of 8 and 48 hr and 15 and 45 days. Eight hr after the tracer, radioactivity was found neither in 18:3 nor its end-product, 22:6, and palmitate was the most highly radioactive component. At longer intervals, 22:6 seemed to retain much of the radioactivity, whereas palmitate showed a precipitous decline in radioactivity. Initial oxidation of linolenate and sparing of the linolenate complexed with polar lipids are discussed. (auth)

• Research Organization: Univ. of California, Los Angeles
• NSA Number: NSA-33-015117
• OSTI ID: 4102009
• Journal Information: Lipids, v. 10, no. 4, pp. 238-241, Journal Name: Lipids, v. 10, no. 4, pp. 238-241; ISSN LPDSA
• Country of Publication: United States
• Language: English

Related Subjects

*BRAIN-- BIOCHEMICAL REACTION KINETICS
*CARBOXYLIC ACIDS-- BIOCHEMICAL REACTION KINETICS
*LINOLENIC ACID-- METABOLISM
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
CARBON 14
N48830* --Life Sciences--New Tracer Techniques--Other
RATS
TRACER TECHNIQUES