Pulmonary function adaptation to ozone in subjects with chronic bronchitis

Journal Article · Fri Jun 01 04:00:00 EDT 1984 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(84)90075-6· OSTI ID:6665504

Kulle, T J; Milman, J H; Sauder, L R; Kerr, H D; Farrell, B P; Miller, W R

Twenty smokers with chronic bronchitis were exposed to 0.41 ppm ozone for 3 hr-day for 5 consecutive days and reexposed 4 days later to determine (1) if they are sensitive to ozone, (2) if they adapt, and (3) if the adaptation lasts longer than 4 days. There were significant decrements in forced vital capacity (FVC) and forced expiratory volume in 3 sec (FEV/sub 3/) on the first day of the 5-day repeated exposures and also on reexposure 4 days following cessation of the sequential exposures. Symptoms experienced were mild and did not predominate on any exposure days. These results suggest that individuals with chronic bronchitis adapt rapidly to ozone and lose this adaptive phenomenon within 4 days. The small decreases seen in FVC and FEV/sub 3/ ( less than or equal to 3%) appear to impose no more than minimal limitations on their daily activities.

• Research Organization: Univ. of Maryland School of Medicine, Baltimore
• OSTI ID: 6665504
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 34:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
BIOLOGICAL ADAPTATION
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BODY
BRONCHITIS
COLLOIDS
DISEASES
DISPERSIONS
FUNCTIONS
LUNGS
ORGANS
OZONE
PATIENTS
RESIDUES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
SMOKES
SOLS
TOBACCO SMOKES