Duration of pulmonary function adaptation to ozone in humans

Journal Article · Sun Oct 31 23:00:00 EST 1982 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668291410657· OSTI ID:5813666

Kulle, T J; Sauder, L R; Kerr, H D; Farrell, B P; Bermel, M S; Smith, D M

The duration of pulmonary function adaptation subsequent to cessation of a 5-day repeated ozone (O/sub 3/) exposure was studied in 24 nonsmoking human subjects. A three-week, 3 hr/day study ws conducted. The subjects received filtered air on Week 1 and 0.4 ppm O/sub 3/ on Week 2. During Week 3, 13 subjects were re-exposed to O/sub 3/ on Friday and 11 were re-exposed to O/sub 3/ on Tuesday. Spirometric measurements (FVC and FEV/sub 1/) and bronchial reactivity to methacholine showed adapation within 2-3 days of the repeated daily exposures (Week 2). Although the duration of adaptation seen with bronchial reactivity appears longer than 7-days, the FVC and FEV/sub 1/ clearly demonstrated complete loss of adaptation by 7 days, with a trend toward significance by 4 days. We concluded, therefore, the loss of ozone adaptation in pulmonary function is a gradual phenomenon lasting less than 7 days following cessation of repeated daily exposures.

• Research Organization: Univ. of Maryland School of Medicine, Baltimore
• OSTI ID: 5813666
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 43:11; ISSN AIHAA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL ADAPTATION
BIOLOGICAL EFFECTS
BODY
DYNAMIC FUNCTION STUDIES
LUNGS
MAMMALS
MAN
ORGANS
OZONE
PRIMATES
RESPIRATORY SYSTEM
VERTEBRATES