Adaptation to ozone: duration of effect

Journal Article · Fri May 01 04:00:00 EDT 1981 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5610743

Horvath, S M; Gliner, J A; Folinsbee, L J

Repeated ozone exposure induces an adaptative response whereby subsequent ozone exposure induces little or no pulmonary function change. The time course of the adaptation and the persistence of this adaptation was determined in 24 subjects. Subjects were studied for 125 min while they exercised intermittently. They were exposed to filtered air for 1 day and then in the next week for 5 consecutive days to 0.5 ppm ozone. After the fifth day, subjects were randomly assigned to return for one more ozone exposure at 1, 2, or 3 wk. The greatest decrement in FEV1 occurred on the second day of exposure. The number of consecutive ozone exposures required to produce adaptation varied from 2 to 5 days. Persistence of adaptation in ozone-sensitive subjects (initial decrease in FEV1 greater than 10%) showed marked individual variability, but the duration of adaptation was shortest for the more sensitive subjects. Adaptation, on the average, lasted for less than 2 wk, being as short as 7 days and as long as 20 days. We concluded that more sensitive subjects required more daily sequential exposures in order to adapt.

• OSTI ID: 5610743
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 123:5; ISSN ARRDA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL ADAPTATION
DOSE-RESPONSE RELATIONSHIPS
EXERCISE
MAMMALS
MAN
OZONE
PRIMATES
SENSITIVITY
TOLERANCE
TOXICITY
VERTEBRATES