Effects of ozone on pulmonary function in normal subjects

Journal Article · Wed Jan 01 04:00:00 EST 1975 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:6288527

Kerr, H D; Kulle, T J; McIlhany, M L; Swidersky, P

Ten smokers and ten nonsmokers were exposed to 0.5 ppM O/sub 3/ for 6 hr, during which time they performed two 15-min exercise stints. Subjective symptoms included chest discomfort, which subsided after exposure, and cough. Functional decrement was most common in those with subjective symptoms. There were nonsmokers were affected most, with decrements in FEV/sub 3/, FEV/sub 1/, FVC, and MMEF. Residual volume increased indicating that reduction in FVC was due to poor emptying rather than hindrance of filling. R/sub L/ increase was significant for nonsmokers only. Difference between smokers and nonsmokers may be a function of select population or decreased response to inhaled irritants. For the group as a whole, the changes in function were: R/sub L/, Gaw, FVC, FEV/sub 3/. There was no significant changes in function for smokers as a group.

• OSTI ID: 6288527
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 111; ISSN ARRDA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL FUNCTIONS
COLLOIDS
DISPERSIONS
HAZARDS
HEALTH HAZARDS
MAMMALS
MAN
OZONE
PRIMATES
RESIDUES
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SMOKES
SOLS
TOBACCO SMOKES
VERTEBRATES