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Bone sarcoma as a second malignant neoplasm in children: influence of radiation and genetic predisposition

Journal Article · · Cancer; (United States)
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Osteosarcoma or chondrosarcoma developed as a second malignant neoplasm (SMN) in 40 of 188 individuals with SMN whose first neoplasm occurred in childhood. A genetic susceptibility to cancer was found in 23; the SMN developed in an irradiated field in 32; both factors were present in 16; neither in one. When a genetic predisposition was present, radiation shortened the interval to SMN. The intervals between tumors and the age at which the bone sarcomas developed in relation to genetic disease and therapy were analyzed by a two-mutation hypothesis.

Research Organization:
Children's Hospital of Philadelphia, PA
OSTI ID:
6664276
Journal Information:
Cancer; (United States), Journal Name: Cancer; (United States) Vol. 46:12; ISSN CANCA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ALKALOIDS
ALKYLATING AGENTS
AMINES
ANIMALS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CHEMOTHERAPY
CHILDREN
CHLORAMBUCIL
DELAYED RADIATION EFFECTS
DISEASES
DRUGS
ENDOXAN
EXTERNAL IRRADIATION
GENETIC EFFECTS
HETEROCYCLIC COMPOUNDS
INDOLES
IRRADIATION
LATENCY PERIOD
MAMMALS
MAN
MEDICINE
MONOCARBOXYLIC ACIDS
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
PYRROLES
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SIDE EFFECTS
SKELETON
THERAPY
VERTEBRATES
VINBLASTINE