Patterns of second malignant neoplasms in children

Conference · Sat Oct 01 04:00:00 EDT 1977 · Cancer, Suppl.; (United States)

OSTI ID:5299872

Meadows, A T ^[1]; D'Angio, G J; Mike, V; Banfi, A; Harris, C; Jenkin, R D.T.; Schwartz, A

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1. Children's Hospital of Philadelphia

A search of the records of 10 pediatric oncology centers revealed 102 children with more than one malignant neoplasm. In this group of 102 patients, all pediatric cancers were seen as initial lesions, but Wilms' tumor and retinoblastoma were over-represented and leukemia and brain tumors underrepresented. Survival variation as well as tumor susceptibility may be responsible for this disproportion. Osteosarcomas and chondrosarcomas were the most frequent second malignant neoplasms (SMN). Embryonal tumors were rare as SMN and adult-type tumors (carcinomas) appeared at earlier than expected ages, whether arising after irradiation or not related to that form of therapy. Radiation was associated with 69 SMN, genetic disease accounted for 27 SMN and both conditions were noted in 15 SMN. In the group of 21 patients for whom neither radiation nor a known genetic disorder could be implicated, there were three with colon carcinoma and glioma and five with leukemia or lymphoma and glioma. These combinations may reflect new tissue-specific hereditary cancer syndromes.

• OSTI ID: 5299872
• Conference Information: Journal Name: Cancer, Suppl.; (United States) Journal Volume: 40:4
• Country of Publication: United States
• Language: English

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