Selection and testing of a rigid, aromatic ligand for binding Gadolinium (III)

Technical Report · Thu Apr 01 04:00:00 EST 1993

OSTI ID:6659434

Burns, T P; Mercer-Smith, J A; Schulte, L D

Paramagnetic compounds are under widespread study as contrast agents in magnetic resonance imaging. These agents increase contrast in magnetic resonance imaging by increasing the relaxation rates of nearby water protons. This report describes a strategy of designing paramagnetic contrast agents with high stability for the paramagnetic metal ion gadolinium(III), low toxicity in vivo, high relativity, and the ability to be covalently attached to antibodies for targeted delivery. Computer modeling of porphyrin analog ligands for gadolinium(III) were used to select sapphyrins for further study. The Gd([sup 3+]) sapphyrins were synthesized and their physical properties were characterized.

• Research Organization: Los Alamos National Lab., NM (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6659434
• Report Number(s): LA-12531-MS; ON: DE93008908
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION SPECTRA
CARBOXYLIC ACIDS
CHELATING AGENTS
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
ELEMENTS
FLUORESCENCE
GADOLINIUM
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LIGANDS
LUMINESCENCE
METALS
NMR IMAGING
NMR SPECTRA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PORPHYRINS
RARE EARTHS
SPECTRA